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Extra assist and checking could possibly be necessary when prescribing for individuals vulnerable to opioid misuse.Observe Carefully (1)mitotane decreases levels of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor. Mitotane is a robust inducer of cytochrome P-4503A4; watch when coadministered with CYP3A4 substr